Dr. Sofia Marchetti investigates antimicrobial defense peptides at Columbia University. Her research focuses on defensin biology, peptide-membrane interactions, and the development of novel antimicrobial strategies against resistant pathogens.
Dr. Marchetti's defensin selectivity optimization platform has produced three lead compounds with enhanced therapeutic indices, now advancing through FDA-guided preclinical evaluation.
An antimicrobial peptide that performed well in broth showed no efficacy in serum. Dr. Marchetti now includes 50% human serum stability testing in every AMP screening cascade.
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